Assay Detail
Functional
CHEMBL4362067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells incubated for 48 hrs by celltiter-Glo assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.09 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568179 | — | — | 1 | 6.70 |
| CHEMBL4582253 | — | — | 1 | 6.22 |
| CHEMBL4561839 | — | — | 1 | 6.22 |
| CHEMBL3954741 | — | — | 1 | 6.22 |
| CHEMBL4435898 | — | — | 1 | 5.96 |
| CHEMBL4515196 | — | — | 1 | 5.96 |
| CHEMBL4443725 | — | — | 1 | 5.89 |
| CHEMBL4534050 | — | — | 1 | 5.52 |
| CHEMBL4464088 | — | — | 1 | 5.46 |
| CHEMBL4445205 | — | — | 1 | 5.43 |
| CHEMBL4471492 | — | — | 1 | 5.42 |
| CHEMBL4439543 | — | — | 1 | 5.40 |
| CHEMBL4470655 | — | — | 1 | 5.24 |
| CHEMBL4515331 | — | — | 1 | 5.23 |
| CHEMBL4446035 | — | — | 1 | 5.14 |
| CHEMBL4445293 | — | — | 1 | 5.14 |
| CHEMBL4593201 | — | — | 1 | 5.14 |
| CHEMBL4553294 | — | — | 1 | 5.12 |
| CHEMBL4592643 | — | — | 1 | 5.12 |
| CHEMBL4590788 | — | — | 1 | 5.11 |
| CHEMBL4454529 | — | — | 1 | 4.95 |
| CHEMBL4457423 | — | — | 1 | 4.92 |
| CHEMBL4469576 | — | — | 1 | 4.92 |
| CHEMBL4442645 | — | — | 1 | 4.90 |
| CHEMBL4440157 | — | — | 1 | 4.88 |
| CHEMBL4451480 | — | — | 1 | 4.80 |
| CHEMBL4470178 | — | — | 1 | 4.79 |
| CHEMBL4444558 | — | — | 1 | 4.78 |
| CHEMBL4543389 | — | — | 1 | 4.69 |
| CHEMBL3944946 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568179 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4582253 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3954741 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4561839 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4435898 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4515196 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4443725 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4534050 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4464088 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4445205 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4471492 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4439543 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4470655 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4515331 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4593201 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4445293 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4446035 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4553294 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4592643 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4590788 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4454529 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4457423 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4469576 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4442645 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4440157 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4451480 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4470178 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4444558 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4543389 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL3944946 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL4560368 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4557779 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL4460281 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL4584437 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL4449020 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4548299 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL4583497 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL4550020 | — | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL4448725 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4520392 | — | IC50 | = | 86100.0 | nM | 4.07 |
| CHEMBL4541368 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3971553 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4471107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4467243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4475865 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3903243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4525215 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4476132 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4573548 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4471204 | — | IC50 | > | 100000.0 | nM | - |