Assay Detail
Functional
CHEMBL4362174
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Antimycobacterial activity against Mycobacterium tuberculosis H37Ra lux incubated for 7 days by luminometric assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.81 | 6.96 |
| MIC90 | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | 4.0 | 2 | 6.96 |
| CHEMBL4455926 | — | — | 2 | 5.89 |
| CHEMBL4521723 | — | — | 2 | 5.81 |
| CHEMBL4561092 | — | — | 2 | 5.75 |
| CHEMBL4443260 | — | — | 2 | 5.60 |
| CHEMBL4456278 | — | — | 2 | 5.52 |
| CHEMBL4458310 | — | — | 2 | 5.16 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4455926 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4521723 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4561092 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4443260 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4456278 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4458310 | — | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL83 | TAMOXIFEN | IC50 | - | — | - | |
| CHEMBL83 | TAMOXIFEN | MIC90 | - | — | - | |
| CHEMBL64 | ISONIAZID | MIC90 | = | 310.0 | nM | - |
| CHEMBL4443260 | — | MIC90 | = | 9230.0 | nM | - |
| CHEMBL4456278 | — | MIC90 | = | 7950.0 | nM | - |
| CHEMBL4521723 | — | MIC90 | = | 4430.0 | nM | - |
| CHEMBL4561092 | — | MIC90 | = | 10220.0 | nM | - |
| CHEMBL4458310 | — | MIC90 | = | 57280.0 | nM | - |
| CHEMBL4455926 | — | MIC90 | = | 6330.0 | nM | - |