Assay Detail
Functional
CHEMBL4362340
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Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.54 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577957 | — | — | 1 | 6.34 |
| CHEMBL4562297 | — | — | 1 | 6.10 |
| CHEMBL4451049 | — | — | 1 | 5.85 |
| CHEMBL4589636 | — | — | 1 | 5.54 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.14 |
| CHEMBL4459518 | — | — | 1 | 5.01 |
| CHEMBL4452177 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577957 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4562297 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4451049 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4589636 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL4459518 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4452177 | — | IC50 | = | 15190.0 | nM | 4.82 |