Assay Detail
Functional
CHEMBL4362647
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Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.37 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451716 | — | — | 1 | 7.62 |
| CHEMBL597855 | — | — | 1 | 7.48 |
| CHEMBL4469509 | — | — | 1 | 7.36 |
| CHEMBL4440834 | — | — | 1 | 7.32 |
| CHEMBL4454799 | — | — | 1 | 6.68 |
| CHEMBL4572989 | — | — | 1 | 6.32 |
| CHEMBL4460199 | — | — | 1 | 6.11 |
| CHEMBL4436063 | — | — | 1 | 6.09 |
| CHEMBL4559684 | — | — | 1 | 5.71 |
| CHEMBL4523003 | — | — | 1 | 5.68 |
| CHEMBL4555042 | — | — | 1 | 5.66 |
| CHEMBL4461042 | — | — | 1 | 5.43 |
| CHEMBL4553777 | — | — | 1 | 5.35 |
| CHEMBL4565597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451716 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL597855 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4469509 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4440834 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4454799 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4572989 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL4460199 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4436063 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4559684 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4523003 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4555042 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4461042 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4553777 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4565597 | — | IC50 | > | 5000.0 | nM | - |