Assay Detail
Functional
CHEMBL4362666
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Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.10 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.52 |
| CHEMBL1201752 | IXABEPILONE | 4.0 | 1 | 8.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.40 |
| CHEMBL4451716 | — | — | 1 | 7.70 |
| CHEMBL597855 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1201752 | IXABEPILONE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4451716 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL597855 | — | IC50 | = | 45.0 | nM | 7.35 |