Assay Detail
Functional
CHEMBL4362909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 7.10 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85059 | — | — | 1 | 8.39 |
| CHEMBL4446893 | — | — | 1 | 8.37 |
| CHEMBL4522134 | — | — | 1 | 8.33 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.24 |
| CHEMBL4466739 | — | — | 1 | 8.14 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.07 |
| CHEMBL4559245 | — | — | 1 | 8.02 |
| CHEMBL4549531 | — | — | 1 | 8.01 |
| CHEMBL4473354 | — | — | 1 | 8.01 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL4530503 | — | — | 1 | 7.96 |
| CHEMBL4443712 | — | — | 1 | 7.89 |
| CHEMBL4476732 | — | — | 1 | 7.89 |
| CHEMBL4465650 | — | — | 1 | 7.82 |
| CHEMBL4457063 | — | — | 1 | 7.77 |
| CHEMBL4575092 | — | — | 1 | 7.68 |
| CHEMBL4444386 | — | — | 1 | 7.52 |
| CHEMBL4583754 | — | — | 1 | 7.46 |
| CHEMBL4540881 | — | — | 1 | 7.31 |
| CHEMBL4574203 | — | — | 1 | 7.28 |
| CHEMBL4525217 | — | — | 1 | 7.24 |
| CHEMBL4458724 | — | — | 1 | 7.13 |
| CHEMBL4559432 | — | — | 1 | 7.08 |
| CHEMBL4560034 | — | — | 1 | 6.96 |
| CHEMBL4461984 | — | — | 1 | 6.92 |
| CHEMBL4474872 | — | — | 1 | 6.77 |
| CHEMBL4450566 | — | — | 1 | 6.68 |
| CHEMBL4522009 | — | — | 1 | 6.44 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.42 |
| CHEMBL4472347 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85059 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4446893 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4522134 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4466739 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4559245 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4549531 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4473354 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4530503 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4443712 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4476732 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4465650 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4457063 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4575092 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4444386 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4583754 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4540881 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4574203 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4525217 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4458724 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4559432 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4560034 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4461984 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4474872 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4450566 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4522009 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4472347 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4580502 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4535880 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4474373 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4435269 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4448112 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4558281 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4561890 | — | EC50 | = | 4420.0 | nM | 5.36 |