Assay Detail
Functional
CHEMBL4362915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against drug resistant HIV-1 harboring reverse transcriptase L100I mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.26 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.31 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.21 |
| CHEMBL4473354 | — | — | 1 | 7.96 |
| CHEMBL85059 | — | — | 1 | 7.77 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.36 |
| CHEMBL4560034 | — | — | 1 | 6.98 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.91 |
| CHEMBL4522009 | — | — | 1 | 5.85 |
| CHEMBL4580502 | — | — | 1 | 5.66 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.50 |
| CHEMBL4448112 | — | — | 1 | 5.36 |
| CHEMBL4472347 | — | — | 1 | 5.17 |
| CHEMBL4474373 | — | — | 1 | 5.09 |
| CHEMBL4558281 | — | — | 1 | 5.05 |
| CHEMBL4435269 | — | — | 1 | 5.00 |
| CHEMBL4535880 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4473354 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL85059 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4560034 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4522009 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4580502 | — | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4448112 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4472347 | — | EC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL4474373 | — | EC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL4558281 | — | EC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL4435269 | — | EC50 | = | 10020.0 | nM | 5.00 |
| CHEMBL4535880 | — | EC50 | = | 10940.0 | nM | 4.96 |