Assay Detail
Binding
CHEMBL4363583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.39 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470503 | — | — | 1 | 8.05 |
| CHEMBL4577187 | — | — | 1 | 8.04 |
| CHEMBL4475477 | — | — | 1 | 8.04 |
| CHEMBL4565471 | — | — | 1 | 7.29 |
| CHEMBL4482951 | — | — | 1 | 7.09 |
| CHEMBL4569748 | — | — | 1 | 7.06 |
| CHEMBL4519299 | — | — | 1 | 7.04 |
| CHEMBL4475435 | — | — | 1 | 6.99 |
| CHEMBL4461778 | — | — | 1 | 6.98 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4440932 | — | — | 1 | 6.59 |
| CHEMBL4440330 | — | — | 1 | 6.54 |
| CHEMBL4472013 | — | — | 1 | 6.50 |
| CHEMBL4474463 | — | — | 1 | 6.46 |
| CHEMBL4455825 | — | — | 1 | 6.45 |
| CHEMBL4476050 | — | — | 1 | 6.43 |
| CHEMBL4538471 | — | — | 1 | 6.36 |
| CHEMBL4448003 | — | — | 1 | 6.32 |
| CHEMBL4461506 | — | — | 1 | 6.30 |
| CHEMBL4453623 | — | — | 1 | 6.30 |
| CHEMBL4474384 | — | — | 1 | 6.29 |
| CHEMBL4446872 | — | — | 1 | 6.29 |
| CHEMBL4463775 | — | — | 1 | 6.21 |
| CHEMBL4593200 | — | — | 1 | 6.19 |
| CHEMBL4444078 | — | — | 1 | 6.14 |
| CHEMBL4586708 | — | — | 1 | 6.14 |
| CHEMBL4469501 | — | — | 1 | 6.13 |
| CHEMBL4521611 | — | — | 1 | 6.13 |
| CHEMBL4525693 | — | — | 1 | 6.12 |
| CHEMBL4464496 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470503 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4577187 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL4475477 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL4565471 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4482951 | — | Ki | = | 81.5 | nM | 7.09 |
| CHEMBL4569748 | — | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL4519299 | — | Ki | = | 91.3 | nM | 7.04 |
| CHEMBL4475435 | — | Ki | = | 101.8 | nM | 6.99 |
| CHEMBL4461778 | — | Ki | = | 105.1 | nM | 6.98 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4440932 | — | Ki | = | 256.4 | nM | 6.59 |
| CHEMBL4440330 | — | Ki | = | 285.5 | nM | 6.54 |
| CHEMBL4472013 | — | Ki | = | 314.1 | nM | 6.50 |
| CHEMBL4474463 | — | Ki | = | 350.4 | nM | 6.46 |
| CHEMBL4455825 | — | Ki | = | 351.7 | nM | 6.45 |
| CHEMBL4476050 | — | Ki | = | 369.6 | nM | 6.43 |
| CHEMBL4538471 | — | Ki | = | 441.4 | nM | 6.36 |
| CHEMBL4448003 | — | Ki | = | 479.4 | nM | 6.32 |
| CHEMBL4461506 | — | Ki | = | 501.7 | nM | 6.30 |
| CHEMBL4453623 | — | Ki | = | 495.5 | nM | 6.30 |
| CHEMBL4474384 | — | Ki | = | 513.5 | nM | 6.29 |
| CHEMBL4446872 | — | Ki | = | 517.7 | nM | 6.29 |
| CHEMBL4463775 | — | Ki | = | 618.4 | nM | 6.21 |
| CHEMBL4593200 | — | Ki | = | 649.0 | nM | 6.19 |
| CHEMBL4444078 | — | Ki | = | 729.9 | nM | 6.14 |
| CHEMBL4586708 | — | Ki | = | 720.3 | nM | 6.14 |
| CHEMBL4469501 | — | Ki | = | 737.1 | nM | 6.13 |
| CHEMBL4521611 | — | Ki | = | 748.1 | nM | 6.13 |
| CHEMBL4525693 | — | Ki | = | 764.2 | nM | 6.12 |
| CHEMBL4464496 | — | Ki | = | 798.8 | nM | 6.10 |
| CHEMBL4516972 | — | Ki | = | 819.3 | nM | 6.09 |
| CHEMBL4540833 | — | Ki | = | 816.3 | nM | 6.09 |
| CHEMBL4573177 | — | Ki | = | 886.7 | nM | 6.05 |
| CHEMBL4443290 | — | Ki | = | 941.1 | nM | 6.03 |
| CHEMBL4586855 | — | Ki | = | 960.2 | nM | 6.02 |
| CHEMBL4550339 | — | Ki | = | 1066.0 | nM | 5.97 |
| CHEMBL4450666 | — | Ki | = | 2125.0 | nM | 5.67 |
| CHEMBL4543874 | — | Ki | = | 3285.0 | nM | 5.48 |
| CHEMBL4457120 | — | Ki | = | 5093.0 | nM | 5.29 |
| CHEMBL4577408 | — | Ki | = | 6092.0 | nM | 5.21 |
| CHEMBL4462700 | — | Ki | = | 7797.0 | nM | 5.11 |