Assay Detail
Binding
CHEMBL4363585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.69 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577408 | — | — | 1 | 9.66 |
| CHEMBL4573177 | — | — | 1 | 9.51 |
| CHEMBL4521611 | — | — | 1 | 9.41 |
| CHEMBL4586855 | — | — | 1 | 9.28 |
| CHEMBL4550339 | — | — | 1 | 9.23 |
| CHEMBL4446872 | — | — | 1 | 9.21 |
| CHEMBL4569748 | — | — | 1 | 9.19 |
| CHEMBL4462700 | — | — | 1 | 9.18 |
| CHEMBL4476050 | — | — | 1 | 9.05 |
| CHEMBL4586708 | — | — | 1 | 9.05 |
| CHEMBL4593200 | — | — | 1 | 9.00 |
| CHEMBL4440330 | — | — | 1 | 8.92 |
| CHEMBL4475435 | — | — | 1 | 8.82 |
| CHEMBL4469501 | — | — | 1 | 8.74 |
| CHEMBL4457120 | — | — | 1 | 8.74 |
| CHEMBL4450666 | — | — | 1 | 8.68 |
| CHEMBL4453623 | — | — | 1 | 8.62 |
| CHEMBL4516972 | — | — | 1 | 8.33 |
| CHEMBL4461778 | — | — | 1 | 8.19 |
| CHEMBL4577187 | — | — | 1 | 8.02 |
| CHEMBL4440932 | — | — | 1 | 7.66 |
| CHEMBL4474463 | — | — | 1 | 7.60 |
| CHEMBL4472013 | — | — | 1 | 7.50 |
| CHEMBL4443290 | — | — | 1 | 7.16 |
| CHEMBL4565471 | — | — | 1 | 7.14 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL4455825 | — | — | 1 | 7.09 |
| CHEMBL4543874 | — | — | 1 | 7.07 |
| CHEMBL4448003 | — | — | 1 | 6.36 |
| CHEMBL4444078 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577408 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL4573177 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL4521611 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL4586855 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL4550339 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL4446872 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL4569748 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL4462700 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL4476050 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4586708 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL4593200 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4440330 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4475435 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4469501 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4457120 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4450666 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4453623 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL4516972 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4461778 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4577187 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL4440932 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL4474463 | — | Ki | = | 25.1 | nM | 7.60 |
| CHEMBL4472013 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL4443290 | — | Ki | = | 68.7 | nM | 7.16 |
| CHEMBL4565471 | — | Ki | = | 71.7 | nM | 7.14 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL4455825 | — | Ki | = | 80.5 | nM | 7.09 |
| CHEMBL4543874 | — | Ki | = | 84.8 | nM | 7.07 |
| CHEMBL4448003 | — | Ki | = | 433.8 | nM | 6.36 |
| CHEMBL4444078 | — | Ki | = | 433.2 | nM | 6.36 |
| CHEMBL4475477 | — | Ki | = | 443.6 | nM | 6.35 |
| CHEMBL4540833 | — | Ki | = | 521.3 | nM | 6.28 |
| CHEMBL4525693 | — | Ki | = | 542.9 | nM | 6.26 |
| CHEMBL4470503 | — | Ki | = | 607.9 | nM | 6.22 |
| CHEMBL4474384 | — | Ki | = | 713.3 | nM | 6.15 |
| CHEMBL4519299 | — | Ki | = | 778.4 | nM | 6.11 |
| CHEMBL4538471 | — | Ki | = | 885.6 | nM | 6.05 |
| CHEMBL4482951 | — | Ki | = | 958.0 | nM | 6.02 |
| CHEMBL4464496 | — | Ki | = | 974.4 | nM | 6.01 |
| CHEMBL4461506 | — | Ki | = | 8695.3 | nM | 5.06 |
| CHEMBL4463775 | — | Ki | = | 9719.5 | nM | 5.01 |