Assay Detail
Functional
CHEMBL4363863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A fluorine scan on the Zn<sup>2+</sup>-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.35 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173445 | LARGAZOLE | — | 1 | 7.36 |
| CHEMBL4470483 | — | — | 1 | 6.77 |
| CHEMBL4524784 | — | — | 1 | 6.09 |
| CHEMBL4559417 | — | — | 1 | 5.18 |
| CHEMBL4562992 | — | — | 1 | - |
| CHEMBL4513302 | — | — | 1 | - |
| CHEMBL4435710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4470483 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4524784 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4559417 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL4562992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4513302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435710 | — | IC50 | > | 10000.0 | nM | - |