Assay Detail
Binding
CHEMBL4363872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human NQO1 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.97 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443793 | — | — | 1 | 6.37 |
| CHEMBL4553527 | — | — | 1 | 4.41 |
| CHEMBL1967497 | — | — | 1 | 4.13 |
| CHEMBL4436961 | — | — | 1 | - |
| CHEMBL4447586 | — | — | 1 | - |
| CHEMBL4468623 | — | — | 1 | - |
| CHEMBL4454218 | — | — | 1 | - |
| CHEMBL4534563 | — | — | 1 | - |
| CHEMBL4435240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443793 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4553527 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL1967497 | — | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL4436961 | — | IC50 | = | 133900.0 | nM | - |
| CHEMBL4447586 | — | IC50 | - | — | - | |
| CHEMBL4468623 | — | IC50 | - | — | - | |
| CHEMBL4454218 | — | IC50 | - | — | - | |
| CHEMBL4534563 | — | IC50 | - | — | - | |
| CHEMBL4435240 | — | IC50 | - | — | - |