Assay Detail
Functional
CHEMBL4363877
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Cytotoxicity against human TOV112D cells transfected with empty vector assessed as reduction in cell viability incubated for 96 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TOV112D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.06 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436961 | — | — | 1 | 5.50 |
| CHEMBL1967497 | — | — | 1 | 5.47 |
| CHEMBL4553527 | — | — | 1 | 5.44 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 5.44 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.97 |
| CHEMBL4435240 | — | — | 1 | 4.37 |
| CHEMBL4447586 | — | — | 1 | 4.21 |
| CHEMBL4534563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436961 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL1967497 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4553527 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL165 | RESVERATROL | IC50 | = | 10670.0 | nM | 4.97 |
| CHEMBL4435240 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL4447586 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL4534563 | — | IC50 | > | 100000.0 | nM | - |