Assay Detail
Binding
CHEMBL4363880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NQO2 in human SKOV3 cells assessed as reduction in cell viability in presence of 1 uM CB1954 and EPR incubated for 24 hrs measured after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ribosyldihydronicotinamide dehydrogenase [quinone] (CHEMBL3959) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.78 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436961 | — | — | 1 | 7.28 |
| CHEMBL1967497 | — | — | 1 | 6.36 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 6.35 |
| CHEMBL4435240 | — | — | 1 | 6.01 |
| CHEMBL4553527 | — | — | 1 | 5.68 |
| CHEMBL4534563 | — | — | 1 | 4.64 |
| CHEMBL4447586 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436961 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1967497 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4435240 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4553527 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL4534563 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL4447586 | — | IC50 | = | 74000.0 | nM | 4.13 |