Assay Detail
Binding
CHEMBL4364406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to AAK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Lysate |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| Kd | 1 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446892 | — | — | 1 | 5.10 |
| CHEMBL577784 | BX-795 | — | 1 | - |
| CHEMBL3605057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446892 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL577784 | BX-795 | Activity | - | — | - | |
| CHEMBL3605057 | — | Activity | - | — | - |