Assay Detail
Binding
CHEMBL4364425
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Binding affinity to biotinylated pre-let-7d microRNA (unknown origin) by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.01 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237124 | MECLOCYCLINE | 2.0 | 1 | 5.24 |
| CHEMBL249837 | METHACYCLINE | 4.0 | 1 | 4.77 |
| CHEMBL2104970 | INCYCLINIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237124 | MECLOCYCLINE | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL249837 | METHACYCLINE | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL2104970 | INCYCLINIDE | Kd | - | — | - |