Assay Detail
Functional
CHEMBL4366249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.68 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 5.77 |
| CHEMBL4520869 | — | — | 1 | 5.08 |
| CHEMBL4461794 | — | — | 1 | 4.91 |
| CHEMBL4528675 | — | — | 1 | 4.87 |
| CHEMBL4467799 | — | — | 1 | 4.81 |
| CHEMBL4439623 | — | — | 1 | 4.74 |
| CHEMBL4529790 | — | — | 1 | 4.73 |
| CHEMBL4452675 | — | — | 1 | 4.72 |
| CHEMBL4444508 | — | — | 1 | 4.72 |
| CHEMBL4529195 | — | — | 1 | 4.72 |
| CHEMBL4443157 | — | — | 1 | 4.65 |
| CHEMBL4513405 | — | — | 1 | 4.64 |
| CHEMBL4466274 | — | — | 1 | 4.63 |
| CHEMBL4578498 | — | — | 1 | 4.62 |
| CHEMBL4450906 | — | — | 1 | 4.61 |
| CHEMBL4460772 | — | — | 1 | 4.60 |
| CHEMBL4535706 | — | — | 1 | 4.58 |
| CHEMBL4519698 | — | — | 1 | 4.55 |
| CHEMBL4468153 | — | — | 1 | 4.55 |
| CHEMBL4584781 | — | — | 1 | 4.52 |
| CHEMBL4544815 | — | — | 1 | 4.47 |
| CHEMBL4475948 | — | — | 1 | 4.46 |
| CHEMBL4462789 | — | — | 1 | 4.45 |
| CHEMBL4438161 | — | — | 1 | 4.44 |
| CHEMBL4549852 | — | — | 1 | 4.40 |
| CHEMBL4473266 | — | — | 1 | 4.40 |
| CHEMBL4468420 | — | — | 1 | - |
| CHEMBL4551072 | — | — | 1 | - |
| CHEMBL4451044 | — | — | 1 | - |
| CHEMBL4550849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4520869 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL4461794 | — | IC50 | = | 12410.0 | nM | 4.91 |
| CHEMBL4528675 | — | IC50 | = | 13440.0 | nM | 4.87 |
| CHEMBL4467799 | — | IC50 | = | 15330.0 | nM | 4.81 |
| CHEMBL4439623 | — | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL4529790 | — | IC50 | = | 18810.0 | nM | 4.73 |
| CHEMBL4452675 | — | IC50 | = | 18920.0 | nM | 4.72 |
| CHEMBL4444508 | — | IC50 | = | 19240.0 | nM | 4.72 |
| CHEMBL4529195 | — | IC50 | = | 19210.0 | nM | 4.72 |
| CHEMBL4443157 | — | IC50 | = | 22580.0 | nM | 4.65 |
| CHEMBL4513405 | — | IC50 | = | 22680.0 | nM | 4.64 |
| CHEMBL4466274 | — | IC50 | = | 23190.0 | nM | 4.63 |
| CHEMBL4578498 | — | IC50 | = | 23890.0 | nM | 4.62 |
| CHEMBL4450906 | — | IC50 | = | 24320.0 | nM | 4.61 |
| CHEMBL4460772 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL4535706 | — | IC50 | = | 26110.0 | nM | 4.58 |
| CHEMBL4519698 | — | IC50 | = | 27910.0 | nM | 4.55 |
| CHEMBL4468153 | — | IC50 | = | 28270.0 | nM | 4.55 |
| CHEMBL4584781 | — | IC50 | = | 30110.0 | nM | 4.52 |
| CHEMBL4544815 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4475948 | — | IC50 | = | 34320.0 | nM | 4.46 |
| CHEMBL4462789 | — | IC50 | = | 35620.0 | nM | 4.45 |
| CHEMBL4438161 | — | IC50 | = | 36080.0 | nM | 4.44 |
| CHEMBL4473266 | — | IC50 | = | 39820.0 | nM | 4.40 |
| CHEMBL4549852 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL4445202 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4571692 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4451792 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4454653 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4564155 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4571676 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4444876 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4587305 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4577338 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4581724 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4444052 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4464019 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4540680 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4546021 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4563627 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4452258 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4578589 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4470593 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4455115 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4558087 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4550849 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4451044 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4551072 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4468420 | — | IC50 | > | 40000.0 | nM | - |