Assay Detail
Binding
CHEMBL4366850
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Inhibition of human CDK2/cyclin-A2 using H1 histone as substrate after 2 hrs by [gamma-33P]-ATP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.99 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554243 | — | — | 1 | 6.08 |
| CHEMBL4446230 | — | — | 1 | 6.04 |
| CHEMBL4467886 | — | — | 1 | 5.98 |
| CHEMBL16171 | WOGONIN | — | 1 | 5.84 |
| CHEMBL4461927 | — | — | 1 | - |
| CHEMBL4463420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554243 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4446230 | — | IC50 | = | 913.0 | nM | 6.04 |
| CHEMBL4467886 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL16171 | WOGONIN | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4461927 | — | IC50 | - | — | - | |
| CHEMBL4463420 | — | IC50 | - | — | - |