Assay Detail
Functional
CHEMBL4366984
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Antiproliferative activity against human A375 cells after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.59 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550982 | — | — | 1 | 8.74 |
| CHEMBL4591755 | — | — | 1 | 8.44 |
| CHEMBL4560897 | — | — | 1 | 8.14 |
| CHEMBL4530505 | — | — | 1 | 8.10 |
| CHEMBL2163631 | SABIZABULIN | 3.0 | 1 | 8.09 |
| CHEMBL4529244 | — | — | 1 | 8.07 |
| CHEMBL4444222 | — | — | 1 | 7.88 |
| CHEMBL4439221 | — | — | 1 | 7.86 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.85 |
| CHEMBL4546922 | — | — | 1 | 7.76 |
| CHEMBL4582258 | — | — | 1 | 7.72 |
| CHEMBL4469884 | — | — | 1 | 7.68 |
| CHEMBL4575966 | — | — | 1 | 7.42 |
| CHEMBL4580938 | — | — | 1 | 7.21 |
| CHEMBL4443758 | — | — | 1 | 7.17 |
| CHEMBL4472104 | — | — | 1 | 6.79 |
| CHEMBL4473183 | — | — | 1 | 6.56 |
| CHEMBL4569965 | — | — | 1 | 6.54 |
| CHEMBL4562103 | — | — | 1 | 6.10 |
| CHEMBL4521087 | — | — | 1 | - |
| CHEMBL4463457 | — | — | 1 | - |
| CHEMBL4453830 | — | — | 1 | - |
| CHEMBL4460001 | — | — | 1 | - |
| CHEMBL4567888 | — | — | 1 | - |
| CHEMBL4458598 | — | — | 1 | - |
| CHEMBL4475704 | — | — | 1 | - |
| CHEMBL4529824 | — | — | 1 | - |
| CHEMBL4569906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550982 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4591755 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4560897 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4530505 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2163631 | SABIZABULIN | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4529244 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4444222 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL4439221 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL107 | COLCHICINE | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL4546922 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL4582258 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL4469884 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL4575966 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL4580938 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL4443758 | — | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL4472104 | — | IC50 | = | 164.2 | nM | 6.79 |
| CHEMBL4473183 | — | IC50 | = | 277.7 | nM | 6.56 |
| CHEMBL4569965 | — | IC50 | = | 285.5 | nM | 6.54 |
| CHEMBL4562103 | — | IC50 | = | 793.4 | nM | 6.10 |
| CHEMBL4521087 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4463457 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4453830 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4460001 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4567888 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4458598 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4475704 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4529824 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4569906 | — | IC50 | > | 1000.0 | nM | - |