Assay Detail
Functional
CHEMBL4367063
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Antiproliferative activity against human A375 cells assessed as cell viability incubated for 72 hrs by cell titer-glo luminescent cell viability assay (Rvb = > 100 uM)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.88 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34704 | — | — | 1 | 5.96 |
| CHEMBL1868007 | — | — | 1 | 5.11 |
| CHEMBL4580612 | — | — | 1 | 4.83 |
| CHEMBL4471766 | — | — | 1 | 4.36 |
| CHEMBL4545319 | — | — | 1 | 4.15 |
| CHEMBL4465165 | — | — | 1 | - |
| CHEMBL4483669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34704 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1868007 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4580612 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4471766 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4545319 | — | IC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL4465165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4483669 | — | IC50 | > | 100000.0 | nM | - |