Assay Detail
Functional
CHEMBL4367766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against promastigote stage of Leishmania infantum MHOM/TN/80/IPT1 assessed as reduction in parasite viability measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.28 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.05 |
| CHEMBL4217754 | — | — | 1 | 6.29 |
| CHEMBL4447772 | — | — | 1 | 6.29 |
| CHEMBL4532864 | — | — | 1 | 6.24 |
| CHEMBL4546470 | — | — | 1 | 6.16 |
| CHEMBL4545723 | — | — | 1 | 6.06 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.84 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4217754 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4447772 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4532864 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4546470 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4545723 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL370143 | PAROMOMYCIN | IC50 | = | 427260.0 | nM | - |