Assay Detail
Functional
CHEMBL4368044
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Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of cytotoxic and Na<sup>+</sup>/K<sup>+</sup>-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.78 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | 1.0 | 1 | 7.72 |
| CHEMBL374839 | — | — | 1 | 6.70 |
| CHEMBL4516416 | — | — | 1 | 5.89 |
| CHEMBL4442486 | — | — | 1 | 5.60 |
| CHEMBL4473157 | — | — | 1 | 5.24 |
| CHEMBL4565716 | — | — | 1 | 4.85 |
| CHEMBL4475094 | — | — | 1 | 4.44 |
| CHEMBL4590717 | — | — | 1 | - |
| CHEMBL4527954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL374839 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4516416 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4442486 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4473157 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4565716 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4475094 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL4590717 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4527954 | — | IC50 | > | 50000.0 | nM | - |