Assay Detail
Functional
CHEMBL4368048
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Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of cytotoxic and Na<sup>+</sup>/K<sup>+</sup>-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.84 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473157 | — | — | 1 | 5.11 |
| CHEMBL4475094 | — | — | 1 | 4.57 |
| CHEMBL4285883 | OLEANDRIN | 1.0 | 1 | - |
| CHEMBL374839 | — | — | 1 | - |
| CHEMBL4590717 | — | — | 1 | - |
| CHEMBL4565716 | — | — | 1 | - |
| CHEMBL4516416 | — | — | 1 | - |
| CHEMBL4442486 | — | — | 1 | - |
| CHEMBL4527954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473157 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4475094 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4285883 | OLEANDRIN | IC50 | - | — | - | |
| CHEMBL374839 | — | IC50 | - | — | - | |
| CHEMBL4590717 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4565716 | — | IC50 | - | — | - | |
| CHEMBL4516416 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4442486 | — | IC50 | - | — | - | |
| CHEMBL4527954 | — | IC50 | - | — | - |