Assay Detail
ADMET
CHEMBL4368049
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Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of cytotoxic and Na<sup>+</sup>/K<sup>+</sup>-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.05 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | 1.0 | 1 | 7.58 |
| CHEMBL374839 | — | — | 1 | 7.00 |
| CHEMBL4442486 | — | — | 1 | 5.35 |
| CHEMBL4516416 | — | — | 1 | 5.24 |
| CHEMBL4473157 | — | — | 1 | 5.10 |
| CHEMBL4475094 | — | — | 1 | - |
| CHEMBL4590717 | — | — | 1 | - |
| CHEMBL4565716 | — | — | 1 | - |
| CHEMBL4527954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL374839 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4442486 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4516416 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4473157 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4475094 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4590717 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4565716 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4527954 | — | IC50 | > | 50000.0 | nM | - |