Assay Detail
Binding
CHEMBL4368992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length NanoLuc-tagged BRD4 (1 to 1362 residues) (unknown origin) expressed in human HCT116 cells after 18 hrs by NanoBRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Brd4 for cancer therapy: inhibitors and degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078100 | AZD-5153 | 1.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078100 | AZD-5153 | IC50 | = | 5.0 | nM | 8.30 |