Assay Detail
Binding
CHEMBL4368994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 in human MM1S cells assessed as down regulation of c-Myc expression after 1 hr by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Brd4 for cancer therapy: inhibitors and degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.38 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078100 | AZD-5153 | 1.0 | 1 | 8.27 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078100 | AZD-5153 | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 329.0 | nM | 6.48 |