Assay Detail
Functional
CHEMBL4369191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream forms after 24 hrs by resazurin dye based fluorescence assay
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 6.07 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.51 |
| CHEMBL3637898 | — | — | 1 | 7.52 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 7.32 |
| CHEMBL3115821 | — | — | 1 | 7.31 |
| CHEMBL3431330 | — | — | 1 | 7.30 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 7.08 |
| CHEMBL3431272 | — | — | 1 | 6.96 |
| CHEMBL3546548 | — | — | 1 | 6.92 |
| CHEMBL2326941 | — | — | 1 | 6.92 |
| CHEMBL2441383 | — | — | 1 | 6.85 |
| CHEMBL1872842 | — | — | 1 | 6.75 |
| CHEMBL3431294 | — | — | 1 | 6.68 |
| CHEMBL545853 | — | — | 1 | 6.66 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 6.52 |
| CHEMBL528966 | — | — | 1 | 6.48 |
| CHEMBL3431166 | — | — | 1 | 6.42 |
| CHEMBL3431223 | — | — | 1 | 6.39 |
| CHEMBL3546405 | — | — | 1 | 6.36 |
| CHEMBL3637896 | — | — | 1 | 6.31 |
| CHEMBL1197563 | — | — | 1 | 6.27 |
| CHEMBL2098184 | — | — | 1 | 6.23 |
| CHEMBL3431099 | — | — | 1 | 6.21 |
| CHEMBL413331 | — | — | 1 | 6.19 |
| CHEMBL3431063 | — | — | 1 | 6.15 |
| CHEMBL1397830 | — | — | 1 | 6.12 |
| CHEMBL530275 | — | — | 1 | 6.08 |
| CHEMBL3637864 | — | — | 1 | 6.06 |
| CHEMBL1836611 | — | — | 1 | 6.01 |
| CHEMBL526813 | — | — | 1 | 6.00 |
| CHEMBL530887 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3637898 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3115821 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3431330 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3431272 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3546548 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2326941 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2441383 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1872842 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3431294 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL545853 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL528966 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3431166 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3431223 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3546405 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3637896 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1197563 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2098184 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3431099 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL413331 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3431063 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1397830 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL530275 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3637864 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1836611 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL526813 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL530887 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2098293 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3637905 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL88430 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL536806 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3431007 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL393580 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL532369 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2171452 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3637895 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL580032 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL238442 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL565436 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1879649 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3637926 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2109740 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2030556 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1308225 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL139814 | — | IC50 | = | 4700.0 | nM | 5.33 |