Assay Detail
Functional
CHEMBL4369508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 72 hrs under hypoxic condition by MTT assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent pyruvate dehydrogenase kinase inhibitors and evaluation of their anti-lung cancer activity under hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.41 | 5.45 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4586099 | — | — | 1 | 5.45 |
| CHEMBL4450236 | — | — | 1 | 5.37 |
| CHEMBL3727577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4586099 | — | EC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL4450236 | — | EC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL3727577 | — | Activity | - | — | - |