Assay Detail
Binding
CHEMBL4369514
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Displacement of [3H]CP55940 from recombinant human CB2 receptor expressed in HEK293 cell membranes measured after 90 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.90 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325937 | — | — | 1 | 6.43 |
| CHEMBL4516385 | — | — | 1 | 6.38 |
| CHEMBL4468889 | — | — | 1 | 6.02 |
| CHEMBL3325451 | — | — | 1 | 6.01 |
| CHEMBL4470914 | — | — | 1 | 5.80 |
| CHEMBL4581847 | — | — | 1 | 5.68 |
| CHEMBL3325938 | — | — | 1 | 5.00 |
| CHEMBL4467592 | — | — | 1 | - |
| CHEMBL4560805 | — | — | 1 | - |
| CHEMBL4463130 | — | — | 1 | - |
| CHEMBL4460499 | — | — | 1 | - |
| CHEMBL4583281 | — | — | 1 | - |
| CHEMBL4463243 | — | — | 1 | - |
| CHEMBL4560895 | — | — | 1 | - |
| CHEMBL4461652 | — | — | 1 | - |
| CHEMBL3325828 | — | — | 1 | - |
| CHEMBL4527367 | — | — | 1 | - |
| CHEMBL4470575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325937 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4516385 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4468889 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL3325451 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL4470914 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL4581847 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL3325938 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4467592 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4560805 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4463130 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4460499 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4583281 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4463243 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4560895 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4461652 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3325828 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4527367 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4470575 | — | Ki | > | 10000.0 | nM | - |