Assay Detail
Functional
CHEMBL4369693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGlu7 receptor expressed in HEK cell co-expressing Galpha15 (unknown origin) assessed as reduction in intracellular Ca2+ mobilization by Fluo-4-AM dye based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 7 (CHEMBL3879) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.33 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162576 | — | — | 1 | 6.84 |
| CHEMBL1585091 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162576 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL1585091 | — | EC50 | = | 1500.0 | nM | 5.82 |