Assay Detail
Binding
CHEMBL4369749
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Inhibition of mushroom tyrosinase diphenolase activity using L-dopa as substrate
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazones with tyrosinase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.82 | 6.37 |
| Ki | 1 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4562624 | — | — | 1 | 6.37 |
| CHEMBL254119 | — | — | 1 | 6.10 |
| CHEMBL4439724 | — | — | 1 | 6.08 |
| CHEMBL239452 | — | — | 1 | 5.91 |
| CHEMBL1779106 | — | — | 1 | 5.85 |
| CHEMBL391982 | — | — | 1 | 5.74 |
| CHEMBL241902 | — | — | 1 | 5.70 |
| CHEMBL1818876 | — | — | 1 | 5.63 |
| CHEMBL1818877 | — | — | 1 | 5.40 |
| CHEMBL1741384 | — | — | 1 | 5.38 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4562624 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL254119 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4439724 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL239452 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1779106 | — | IC50 | = | 1406.0 | nM | 5.85 |
| CHEMBL391982 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL241902 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1818876 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL1818877 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL1741384 | — | IC50 | = | 4148.0 | nM | 5.38 |
| CHEMBL287556 | KOJIC ACID | Ki | = | 20000.0 | nM | 4.70 |