Assay Detail
Binding
CHEMBL4369757
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Inhibition of tyrosinase in mouse B16 cells using L-DOPA as substrate preincubated for 72 hrs followed by substrate addition and measured after 30 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazones with tyrosinase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.54 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329471 | — | — | 1 | 5.92 |
| CHEMBL74689 | PHENYL(METHYL)THIOSEMICARBAZONE | — | 1 | 5.70 |
| CHEMBL243185 | PHENYLTHIOSEMICARBAZONE | — | 1 | 4.99 |
| CHEMBL398206 | — | — | 1 | - |
| CHEMBL440504 | — | — | 1 | - |
| CHEMBL1779098 | — | — | 1 | - |
| CHEMBL4540846 | — | — | 1 | - |
| CHEMBL4435353 | — | — | 1 | - |
| CHEMBL4593432 | — | — | 1 | - |
| CHEMBL4440593 | — | — | 1 | - |
| CHEMBL4472027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329471 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL74689 | PHENYL(METHYL)THIOSEMICARBAZONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL243185 | PHENYLTHIOSEMICARBAZONE | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL398206 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL440504 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1779098 | — | IC50 | < | 2300.0 | nM | - |
| CHEMBL4540846 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4435353 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4593432 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4440593 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4472027 | — | IC50 | < | 1000.0 | nM | - |