Assay Detail
Binding
CHEMBL4369922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and in Vivo Characterization of A<sub>1</sub> Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.55 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1877326 | — | — | 1 | 9.85 |
| CHEMBL4562258 | — | — | 1 | 9.70 |
| CHEMBL284969 | — | — | 1 | 9.68 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.66 |
| CHEMBL4533718 | — | — | 1 | 9.43 |
| CHEMBL464859 | NECA | — | 1 | 9.35 |
| CHEMBL4463802 | — | — | 1 | 9.35 |
| CHEMBL4436786 | — | — | 1 | 9.28 |
| CHEMBL4468006 | — | — | 1 | 9.19 |
| CHEMBL331291 | — | — | 1 | 9.17 |
| CHEMBL4439013 | — | — | 1 | 9.15 |
| CHEMBL4554295 | — | — | 1 | 8.98 |
| CHEMBL4587144 | — | — | 1 | 8.98 |
| CHEMBL4579650 | — | — | 1 | 8.81 |
| CHEMBL4556466 | — | — | 1 | 8.73 |
| CHEMBL4470080 | — | — | 1 | 8.61 |
| CHEMBL4436917 | — | — | 1 | 8.45 |
| CHEMBL2012686 | — | — | 1 | 8.28 |
| CHEMBL4522864 | — | — | 1 | 7.95 |
| CHEMBL4473739 | — | — | 1 | 7.60 |
| CHEMBL4584140 | — | — | 1 | 5.60 |
| CHEMBL4470730 | — | — | 1 | 5.52 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1877326 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL4562258 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL284969 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL4533718 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL464859 | NECA | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL4463802 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL4436786 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL4468006 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL331291 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL4439013 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL4554295 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL4587144 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL4579650 | — | Ki | = | 1.56 | nM | 8.81 |
| CHEMBL4556466 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL4470080 | — | Ki | = | 2.47 | nM | 8.61 |
| CHEMBL4436917 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL2012686 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4522864 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL4473739 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL4584140 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL4470730 | — | Ki | = | 2990.0 | nM | 5.52 |
| CHEMBL1643 | RIBAVIRIN | Ki | = | 4430.0 | nM | 5.35 |