Assay Detail
Binding
CHEMBL4370053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol hexakisphosphate kinase 2 (CHEMBL4523488) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.41 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 6.30 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.16 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.16 |
| CHEMBL90568 | DIOSMETIN | — | 1 | 6.05 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.89 |
| CHEMBL312163 | RHAMNETIN | — | 1 | 5.75 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.60 |
| CHEMBL243664 | ACACETIN | — | 1 | 5.24 |
| CHEMBL28 | APIGENIN | — | 1 | 5.15 |
| CHEMBL243677 | — | — | 1 | 5.10 |
| CHEMBL222556 | — | — | 1 | 4.94 |
| CHEMBL484663 | — | — | 1 | 4.89 |
| CHEMBL294878 | — | — | 1 | 4.74 |
| CHEMBL210635 | GENKWANIN | — | 1 | 4.62 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 4.60 |
| CHEMBL484662 | — | — | 1 | - |
| CHEMBL9352 | NARINGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379064 | ISORHAMNETIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL50 | QUERCETIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL164 | MYRICETIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL90568 | DIOSMETIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL312163 | RHAMNETIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL243664 | ACACETIN | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL28 | APIGENIN | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL243677 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL222556 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL484663 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL294878 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL210635 | GENKWANIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL484662 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL9352 | NARINGENIN | IC50 | > | 30000.0 | nM | - |