Assay Detail
Functional
CHEMBL4370077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 infected in human TZM-bl cells after 2 days by luciferase-bright glo assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.87 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3929927 | — | — | 1 | 8.94 |
| CHEMBL4446946 | — | — | 1 | 8.66 |
| CHEMBL4539129 | — | — | 1 | 8.66 |
| CHEMBL4574049 | — | — | 1 | 8.34 |
| CHEMBL4533747 | — | — | 1 | 8.32 |
| CHEMBL4463813 | — | — | 1 | 8.06 |
| CHEMBL4452511 | — | — | 1 | 8.05 |
| CHEMBL4561641 | — | — | 1 | 8.00 |
| CHEMBL4587500 | — | — | 1 | 7.99 |
| CHEMBL4442381 | — | — | 1 | 7.98 |
| CHEMBL4464951 | — | — | 1 | 7.86 |
| CHEMBL4436654 | — | — | 1 | 7.80 |
| CHEMBL4529503 | — | — | 1 | 7.78 |
| CHEMBL4513621 | — | — | 1 | 7.50 |
| CHEMBL4544720 | — | — | 1 | 7.38 |
| CHEMBL4572037 | — | — | 1 | 7.29 |
| CHEMBL4528160 | — | — | 1 | 7.25 |
| CHEMBL4452317 | — | — | 1 | 6.98 |
| CHEMBL4542587 | — | — | 1 | 6.68 |
| CHEMBL4444251 | — | — | 1 | - |
| CHEMBL4466022 | — | — | 1 | - |
| CHEMBL4445987 | — | — | 1 | - |
| CHEMBL4591122 | — | — | 1 | - |
| CHEMBL4524430 | — | — | 1 | - |
| CHEMBL4466361 | — | — | 1 | - |
| CHEMBL4453494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3929927 | — | EC50 | = | 1.16 | nM | 8.94 |
| CHEMBL4446946 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4539129 | — | EC50 | = | 2.21 | nM | 8.66 |
| CHEMBL4574049 | — | EC50 | = | 4.53 | nM | 8.34 |
| CHEMBL4533747 | — | EC50 | = | 4.76 | nM | 8.32 |
| CHEMBL4463813 | — | EC50 | = | 8.69 | nM | 8.06 |
| CHEMBL4452511 | — | EC50 | = | 8.95 | nM | 8.05 |
| CHEMBL4561641 | — | EC50 | = | 9.98 | nM | 8.00 |
| CHEMBL4587500 | — | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL4442381 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4464951 | — | EC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4436654 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4529503 | — | EC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4513621 | — | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL4544720 | — | EC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4572037 | — | EC50 | = | 50.7 | nM | 7.29 |
| CHEMBL4528160 | — | EC50 | = | 55.7 | nM | 7.25 |
| CHEMBL4452317 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4542587 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4444251 | — | EC50 | > | 251.0 | nM | - |
| CHEMBL4466022 | — | EC50 | > | 217.0 | nM | - |
| CHEMBL4445987 | — | EC50 | > | 232.0 | nM | - |
| CHEMBL4591122 | — | EC50 | > | 232.0 | nM | - |
| CHEMBL4524430 | — | EC50 | > | 217.0 | nM | - |
| CHEMBL4466361 | — | EC50 | > | 250.0 | nM | - |
| CHEMBL4453494 | — | EC50 | > | 237.0 | nM | - |