Assay Detail
Binding
CHEMBL4370290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.53 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.82 |
| CHEMBL4460381 | — | — | 1 | 8.60 |
| CHEMBL4473768 | — | — | 1 | 8.00 |
| CHEMBL4541014 | — | — | 1 | 7.64 |
| CHEMBL4569885 | — | — | 1 | 7.52 |
| CHEMBL4546122 | — | — | 1 | 7.28 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 6.85 |
| CHEMBL4552482 | — | — | 1 | 6.56 |
| CHEMBL4572443 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4460381 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4473768 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4541014 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4569885 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4546122 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL535 | SUNITINIB | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4552482 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4572443 | — | IC50 | = | 326.0 | nM | 6.49 |