Assay Detail
Binding
CHEMBL4370319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human GST-tagged ERalpha LBD expressed in baculovirus-infected insect cells by lantha screen assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.40 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583286 | — | — | 1 | 9.50 |
| CHEMBL4448852 | — | — | 1 | 9.50 |
| CHEMBL4436390 | — | — | 1 | 9.50 |
| CHEMBL4584370 | — | — | 1 | 9.40 |
| CHEMBL4436187 | — | — | 1 | 9.40 |
| CHEMBL4586022 | — | — | 1 | 9.30 |
| CHEMBL4517931 | — | — | 1 | 9.00 |
| CHEMBL4518390 | — | — | 1 | 8.90 |
| CHEMBL4462367 | — | — | 1 | 8.90 |
| CHEMBL4515724 | — | — | 1 | 8.80 |
| CHEMBL4536148 | — | — | 1 | 8.80 |
| CHEMBL4536329 | — | — | 1 | 8.40 |
| CHEMBL4541930 | — | — | 1 | 8.00 |
| CHEMBL4586630 | — | — | 1 | 7.70 |
| CHEMBL4515274 | — | — | 1 | 7.60 |
| CHEMBL3775824 | — | — | 1 | 7.60 |
| CHEMBL4451617 | — | — | 1 | 6.50 |
| CHEMBL4554684 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583286 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4448852 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4436390 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4584370 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4436187 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4586022 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4517931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4518390 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4462367 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4515724 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4536148 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4536329 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4541930 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4586630 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4515274 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3775824 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4451617 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4554684 | — | IC50 | = | 39810.72 | nM | 4.40 |