Assay Detail
Binding
CHEMBL4370320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ERalpha degradation in human MCF7 cells after 18 to 24 hrs by in multiplexed cell assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.94 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583286 | — | — | 1 | 9.70 |
| CHEMBL4448852 | — | — | 1 | 9.60 |
| CHEMBL4515724 | — | — | 1 | 9.50 |
| CHEMBL4586022 | — | — | 1 | 9.50 |
| CHEMBL4436187 | — | — | 1 | 9.40 |
| CHEMBL4584370 | — | — | 1 | 9.20 |
| CHEMBL4541930 | — | — | 1 | 9.20 |
| CHEMBL4536148 | — | — | 1 | 9.20 |
| CHEMBL4462367 | — | — | 1 | 9.10 |
| CHEMBL4436390 | — | — | 1 | 9.10 |
| CHEMBL4517931 | — | — | 1 | 9.00 |
| CHEMBL4586630 | — | — | 1 | 8.80 |
| CHEMBL4536329 | — | — | 1 | 8.60 |
| CHEMBL3775824 | — | — | 1 | 8.40 |
| CHEMBL4518390 | — | — | 1 | 8.20 |
| CHEMBL4515274 | — | — | 1 | 8.20 |
| CHEMBL4451617 | — | — | 1 | 7.20 |
| CHEMBL4554684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583286 | — | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL4448852 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL4515724 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4586022 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4436187 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4584370 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL4541930 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL4536148 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL4462367 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4436390 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4517931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4586630 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4536329 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3775824 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4518390 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4515274 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4451617 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4554684 | — | IC50 | > | 10000.0 | nM | - |