Assay Detail
Binding
CHEMBL4370472
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Inhibition of 20S immunoproteasome beta 2 in intact human RPMI8226 cells after 1 hr by competitive ABPP assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.86 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577205 | — | — | 1 | 6.91 |
| CHEMBL4513509 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577205 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4513509 | — | IC50 | = | 159.0 | nM | 6.80 |