Assay Detail
Binding
CHEMBL4370675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.85 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.46 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.40 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.30 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.26 |
| CHEMBL28 | APIGENIN | — | 1 | 6.10 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.05 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.05 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.00 |
| CHEMBL28626 | MORIN | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31574 | FISETIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL50 | QUERCETIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL28 | APIGENIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL164 | MYRICETIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL117 | CHRYSIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL28626 | MORIN | IC50 | = | 10000.0 | nM | 5.00 |