Assay Detail
Functional
CHEMBL4370759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.57 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 6.70 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.40 |
| CHEMBL4457648 | — | — | 1 | 6.10 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.05 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.70 |
| CHEMBL258513 | — | — | 1 | 5.68 |
| CHEMBL4444879 | — | — | 1 | 5.64 |
| CHEMBL4451679 | — | — | 1 | 4.55 |
| CHEMBL4472636 | — | — | 1 | 4.50 |
| CHEMBL4465861 | — | — | 1 | 4.39 |
| CHEMBL4455495 | — | — | 1 | - |
| CHEMBL4448367 | — | — | 1 | - |
| CHEMBL4591655 | — | — | 1 | - |
| CHEMBL4562026 | — | — | 1 | - |
| CHEMBL4467889 | — | — | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL4442171 | — | — | 1 | - |
| CHEMBL4531506 | — | — | 1 | - |
| CHEMBL4453285 | — | — | 1 | - |
| CHEMBL4591403 | — | — | 1 | - |
| CHEMBL4442373 | — | — | 1 | - |
| CHEMBL4436405 | — | — | 1 | - |
| CHEMBL4445460 | — | — | 1 | - |
| CHEMBL4452881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4457648 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL258513 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4444879 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4451679 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4472636 | — | EC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL4465861 | — | EC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL4455495 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4448367 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4591655 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4562026 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4467889 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | EC50 | > | 250000.0 | nM | - |
| CHEMBL4442171 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4531506 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4453285 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4591403 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4442373 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4436405 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4445460 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4452881 | — | EC50 | > | 100000.0 | nM | - |