Assay Detail
Binding
CHEMBL4370796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PI3Kbeta using PIP2 as substrate after 35 to 40 mins by HTRF assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.16 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554894 | — | — | 1 | 5.27 |
| CHEMBL4467692 | — | — | 1 | 5.05 |
| CHEMBL4530810 | — | — | 1 | - |
| CHEMBL4453747 | — | — | 1 | - |
| CHEMBL4514389 | — | — | 1 | - |
| CHEMBL4528263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554894 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4467692 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4530810 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453747 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4514389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4528263 | — | IC50 | > | 10000.0 | nM | - |