Assay Detail
Functional
CHEMBL4370845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against X4 tropic HIV-1 NL4-3 infected in human MT4 cells assessed as protection against virus-induced cytopathic effect in absence of ZnCl2 after 5 days by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.35 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532299 | — | — | 1 | 8.19 |
| CHEMBL4548792 | — | — | 1 | 7.40 |
| CHEMBL4568686 | — | — | 1 | 7.40 |
| CHEMBL4529751 | — | — | 1 | 6.96 |
| CHEMBL4448291 | — | — | 1 | 6.85 |
| CHEMBL4451705 | — | — | 1 | 6.77 |
| CHEMBL4457992 | — | — | 1 | 6.66 |
| CHEMBL4531581 | — | — | 1 | 6.33 |
| CHEMBL4452806 | — | — | 1 | 6.24 |
| CHEMBL4531818 | — | — | 1 | 6.23 |
| CHEMBL4469099 | — | — | 1 | 6.17 |
| CHEMBL4564854 | — | — | 1 | 6.17 |
| CHEMBL4587288 | — | — | 1 | 6.12 |
| CHEMBL4571487 | — | — | 1 | 6.11 |
| CHEMBL4443369 | — | — | 1 | 6.10 |
| CHEMBL4460850 | — | — | 1 | 6.10 |
| CHEMBL4462763 | — | — | 1 | 6.10 |
| CHEMBL4590559 | — | — | 1 | 6.04 |
| CHEMBL4457538 | — | — | 1 | 6.00 |
| CHEMBL4521018 | — | — | 1 | 5.72 |
| CHEMBL4462478 | — | — | 1 | 5.58 |
| CHEMBL4470669 | — | — | 1 | 5.51 |
| CHEMBL4442334 | — | — | 1 | 5.38 |
| CHEMBL4459026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532299 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4548792 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4568686 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4529751 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4448291 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4451705 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4457992 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4531581 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4452806 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4531818 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4469099 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4564854 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4587288 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4571487 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4443369 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4460850 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4462763 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4590559 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4457538 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4521018 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4462478 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4470669 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4442334 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4459026 | — | EC50 | > | 970.0 | nM | - |