Assay Detail
Binding
CHEMBL4370865
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Inhibition of TDO (unknown origin)
4
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.79 | 7.52 |
| EC50 | 1 | 7.11 | 7.11 |
| Ki | 1 | 5.26 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3628602 | — | — | 1 | 7.52 |
| CHEMBL4166624 | — | — | 1 | 7.11 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 6.05 |
| CHEMBL1812545 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3628602 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4166624 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1812545 | — | Ki | = | 5500.0 | nM | 5.26 |