Assay Detail
Binding
CHEMBL4371127
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Inhibition of human androgen receptor
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.76 | 8.05 |
| Ki | 3 | 7.73 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447539 | — | — | 2 | 8.05 |
| CHEMBL4548397 | — | — | 2 | 7.96 |
| CHEMBL6874 | — | — | 2 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447539 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4548397 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4548397 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4447539 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL6874 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL6874 | — | IC50 | = | 27.0 | nM | 7.57 |