Assay Detail
Functional
CHEMBL4371156
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Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.57 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.70 |
| CHEMBL188799 | — | — | 1 | 9.15 |
| CHEMBL189709 | — | — | 1 | 9.00 |
| CHEMBL360390 | — | — | 1 | 8.52 |
| CHEMBL188798 | — | — | 1 | 8.40 |
| CHEMBL186655 | — | — | 1 | 8.30 |
| CHEMBL364610 | — | — | 1 | 8.10 |
| CHEMBL360407 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL188799 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL189709 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL360390 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL188798 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL186655 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL364610 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL360407 | — | IC50 | = | 40.0 | nM | 7.40 |