Assay Detail
Functional
CHEMBL4372466
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Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Strategies To Activate the Dopamine D<sub>1</sub> Receptor: Recent Advances in Orthosteric Agonism and Positive Allosteric Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.65 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441343 | PARABEN | — | 1 | 8.96 |
| CHEMBL3421729 | MEVIDALEN | 2.0 | 1 | 8.96 |
| CHEMBL3421836 | — | — | 1 | 8.44 |
| CHEMBL3421730 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441343 | PARABEN | EC50 | = | 1.11 | nM | 8.96 |
| CHEMBL3421729 | MEVIDALEN | EC50 | = | 1.11 | nM | 8.96 |
| CHEMBL3421836 | — | EC50 | = | 3.66 | nM | 8.44 |
| CHEMBL3421730 | — | EC50 | = | 5.8 | nM | 8.24 |