Assay Detail
Functional
CHEMBL4372502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV 1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 8.44 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3291180 | — | — | 1 | 10.52 |
| CHEMBL3291176 | — | — | 1 | 10.40 |
| CHEMBL4554205 | — | — | 1 | 10.05 |
| CHEMBL4447207 | — | — | 1 | 9.70 |
| CHEMBL3291209 | — | — | 1 | 9.52 |
| CHEMBL3291178 | — | — | 1 | 9.52 |
| CHEMBL4575430 | — | — | 1 | 9.52 |
| CHEMBL4472391 | — | — | 1 | 9.40 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.30 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.22 |
| CHEMBL4588457 | — | — | 1 | 9.15 |
| CHEMBL1818349 | — | — | 1 | 9.10 |
| CHEMBL4563280 | — | — | 1 | 9.10 |
| CHEMBL85946 | — | — | 1 | 9.05 |
| CHEMBL4527855 | — | — | 1 | 9.05 |
| CHEMBL4456718 | — | — | 1 | 9.05 |
| CHEMBL85947 | — | — | 1 | 9.00 |
| CHEMBL236161 | — | — | 1 | 9.00 |
| CHEMBL396816 | — | — | 1 | 8.72 |
| CHEMBL239281 | — | — | 1 | 8.52 |
| CHEMBL4584281 | — | — | 1 | 8.40 |
| CHEMBL4585633 | — | — | 1 | 8.40 |
| CHEMBL1818348 | — | — | 1 | 8.40 |
| CHEMBL4475177 | — | — | 1 | 8.30 |
| CHEMBL4457416 | — | — | 1 | 8.30 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.15 |
| CHEMBL4579437 | — | — | 1 | 8.15 |
| CHEMBL4472602 | — | — | 1 | 8.10 |
| CHEMBL4555689 | — | — | 1 | 8.05 |
| CHEMBL4576682 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3291180 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3291176 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4554205 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL4447207 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3291209 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3291178 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4575430 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4472391 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4588457 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1818349 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4563280 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4456718 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL85946 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4527855 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL85947 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL236161 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL396816 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL239281 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4584281 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4585633 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1818348 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4475177 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4457416 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4579437 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4472602 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4555689 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4576682 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4459861 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1818350 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3291210 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4466305 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4463547 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4441773 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4451811 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4563300 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL368172 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4460357 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4472080 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4456398 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3291188 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3291186 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4459968 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3291190 | — | EC50 | = | 580.0 | nM | 6.24 |