Assay Detail
Binding
CHEMBL4373003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.05 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448325 | — | — | 1 | 8.57 |
| CHEMBL4457529 | — | — | 1 | 8.40 |
| CHEMBL4540910 | — | — | 1 | 8.29 |
| CHEMBL4470576 | — | — | 1 | 8.24 |
| CHEMBL4466764 | — | — | 2 | 8.22 |
| CHEMBL4583118 | — | — | 2 | 8.21 |
| CHEMBL4588948 | — | — | 1 | 8.21 |
| CHEMBL4446498 | — | — | 1 | 8.17 |
| CHEMBL4518492 | — | — | 2 | 8.13 |
| CHEMBL4564586 | — | — | 1 | 8.05 |
| CHEMBL4593810 | — | — | 1 | 8.03 |
| CHEMBL4587382 | — | — | 1 | 8.00 |
| CHEMBL4528544 | — | — | 1 | 7.99 |
| CHEMBL4541837 | — | — | 1 | 7.98 |
| CHEMBL4466080 | — | — | 1 | 7.96 |
| CHEMBL4457389 | — | — | 1 | 7.80 |
| CHEMBL4563802 | — | — | 1 | 7.76 |
| CHEMBL4533366 | — | — | 1 | 7.68 |
| CHEMBL4445116 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448325 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4457529 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4540910 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4470576 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4466764 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4588948 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4583118 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4446498 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4518492 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4583118 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4466764 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4564586 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4593810 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4587382 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4528544 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4541837 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4466080 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4457389 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL4563802 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL4518492 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4533366 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4445116 | — | IC50 | = | 29.4 | nM | 7.53 |