Assay Detail
Functional
CHEMBL4373063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC9 cells harboring EGFR exon-19 del mutant after 72 hrs by EZ-Cytox assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Click chemistry for improvement in selectivity of quinazoline-based kinase inhibitors for mutant epidermal growth factor receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.82 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 10.00 |
| CHEMBL4521506 | — | — | 1 | 9.22 |
| CHEMBL4460706 | — | — | 1 | 9.05 |
| CHEMBL4454948 | — | — | 1 | 9.05 |
| CHEMBL4515526 | — | — | 1 | 9.00 |
| CHEMBL4436695 | — | — | 1 | 8.96 |
| CHEMBL4578487 | — | — | 1 | 8.92 |
| CHEMBL4468464 | — | — | 1 | 8.92 |
| CHEMBL4563683 | — | — | 1 | 8.89 |
| CHEMBL4476544 | — | — | 1 | 8.82 |
| CHEMBL3787386 | — | — | 1 | 8.54 |
| CHEMBL4584413 | — | — | 1 | 8.44 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.21 |
| CHEMBL4575267 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4521506 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4460706 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4454948 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4515526 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4436695 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4578487 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4468464 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4563683 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4476544 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3787386 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4584413 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4575267 | — | IC50 | = | 32.0 | nM | 7.50 |