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Assay Detail

CHEMBL4373136

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ADMET
Cytotoxicity against CHO cells after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K.
J Med Chem (2019) 62 : 1022 -1035
PubMed 30562027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.16 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4443956 1 6.12
CHEMBL4464908 1 5.78
CHEMBL4459380 1 5.37
CHEMBL4466654 1 5.32
CHEMBL4571751 1 5.30
CHEMBL4549480 1 5.22
CHEMBL4468890 1 5.15
CHEMBL4457843 1 5.07
CHEMBL4577940 1 4.89
CHEMBL4576616 1 4.75
CHEMBL4448152 1 4.60
CHEMBL4539500 1 4.35
CHEMBL4465063 1 -
CHEMBL4591240 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4443956 IC50 = 750.0 nM 6.12
CHEMBL4464908 IC50 = 1660.0 nM 5.78
CHEMBL4459380 IC50 = 4300.0 nM 5.37
CHEMBL4466654 IC50 = 4840.0 nM 5.32
CHEMBL4571751 IC50 = 5020.0 nM 5.30
CHEMBL4549480 IC50 = 6060.0 nM 5.22
CHEMBL4468890 IC50 = 7030.0 nM 5.15
CHEMBL4457843 IC50 = 8480.0 nM 5.07
CHEMBL4577940 IC50 = 13000.0 nM 4.89
CHEMBL4576616 IC50 = 17580.0 nM 4.75
CHEMBL4448152 IC50 = 25000.0 nM 4.60
CHEMBL4539500 IC50 = 45000.0 nM 4.35
CHEMBL4465063 IC50 > 272000.0 nM -
CHEMBL4591240 IC50 > 222000.0 nM -